Patients with Chronic Lymphocytic Leukemia are more Likely to Have TP53 Gene Mutations

Objective: The purpose was to quantify the prevalence of Tp53 gene mutation in chronic lymphocytic leukemia patients.. Study Design: Cross-sectional/ Descriptive study Place and Duration: This conducted multiple centres including Mayo Hospital Lahore Liaquat University Medical Health Sciences duration from August, 2022 January, 2023. Methods: Total 112 cases leukaemia were included this study. All patients received at laboratory for TP53 analysis. To identify using FISH method, five ml whole blood or one bone marrow aspirate sample taken. Data input analysis done with help statistical package social sciences 22. Results: mean age 52.8±6.52 years had BMI 23.7±14.52 kg/m2. Seventy-three (65.2%) males 39 (34.8%) females. There 52 (46.4%) educated 60 (53.6%) non educated. We found frequency 17 (15.2%) which 11 6 Among mutation, 8 >50 years, aged between 30-50 3 18-30 years. Conclusion: concluded that 15.2% majority Keywords: CLL, Tumour suppressor gene, Chronic leukaemia, FISH, TP53, Fluorescence Situ hybridization